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KMID : 0620920180500030005
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Experimental & Molecular Medicine
2018 Volume.50 No. 3 p.5 ~ p.5
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Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
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Wang Sung-Eun
Kim Hae-Bom
Kim Yong-Seok
Jo Sung-Sin
Lee Seung-Hoon
Jung Sung-Jun
Son Hyeon
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Abstract
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Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity. We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.
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KEYWORD
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Epigenetics, Neuroscience
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